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X-Linked Pure Familial Spastic Paraparesis Arch Neurol 52:665-669, Cambi,F.,et al, 1995 See this aricle in Pubmed Article Abstract The disease is characterized by spastic gait and increased reflexes without other associated neurologic signs.No male-to-male transmission has been documented in this pedigree.Magnetic resonance images of the brain in affected individuals demonstrate discrete white matter lesions in the periatrial regions,more prominent posteriorly.Similar,although not as extensive,white matter lesions were detected in the brain of the single obligate female carrier studied with MRI.We report previously undescribed (to our knowledge)findings of MRI in pure X-linked familial spastic paraparesis and discuss the use of MRI in the diagnosis of this disorder and as a possible screening study of potential carriers.

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(click to filter results - removes previous filter) familial gait,spastic genetic neurologic disorders hyperreflexia MRI MRI,abnormal paraparesis paraparesis,familial spastic paraparesis,spastic spasticity white matter disease

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